번역샘플 - 재료과학 및 공학(MaterialScience&Engineering)

The final objectives of this study are to perform a visual observation evaluation of the crystallization style of Octacalcium phosphate [OCP: Ca8(PO4)4(HPO4)2・5H2O] on porous molded bodies from biocompatible polymers and the bonding state of biocompatible polymers and OCP crystal interfaces, and a evaluation of the mechanical properties of biocompatible polymers crystallized by OCP, to gain foundational knowledge on the mechanism for forming bone and bone-like bone graft materials. Here, as it was a 1-year investigation, we selected gelatin, which has biocompatible polymers and for which the cancellous bone porous body preparation method has already been established, and focused on the evaluation of this OCP formation mechanism. This mechanism is an essential part of bone formation calcification and is of pivotal importance for high mechanical strength in bones and manifestations of flexibility. Not only this、it is also essential for the preparation of the high-functionality biomaterials to which it is applied. Therefore, by combining the two evaluations of the evaluation of the crystal interface and microscale, and evaluation of the mechanical strength of macro formation, mutual feedback could be provided on the influence that micro-generated phenomena have on bulk, we could obtain knowledge over a wide range not possible with a unidirectional investigation.
OCP is a main inorganic component of bones, and is mainly composed of highly biocompatible materials. Not only that. As this unique crystal structure is able to carry drugs inside the crystal structure, it shows promise as a raw material for new combination medical materials. On the other hand, OCP, and above all, with drug-carrying OCP itself, it is difficult to obtain molded bodies with the appropriate size and strength as bone graft material. When OCP powder is simply kneaded into biocompatible polymers, it does not become a material with the flexibility of bone, so the crystallization process on the bone is very important. Controlling OCP crystallization promises to enable preparation of biomaterials with “suppleness” like bone.