PhD, Biology and Pharmacology

에디터 소개글

탄탄한 연구 배경을 갖춘 부교수입니다. 피어리뷰 논문 60편을 출판한 저자이며, 10차례의 국내외 학술대회에서 발표했습니다. 미국생리학회(American Physiology Society), 미국소화기능성질환 운동학회(American Neurogastroenterology and Motility Society), 미국약리학회(American Society of Pharmacology and Experimental Therapeutics)에 가입해 있습니다.

전문분야

Animal Science, Biology, Pharmacology

학력

PhD, Houston Department of Integrative Biology and Pharmacology, University of Texas Medical School BS, Animal Science, Texas A&M University, College Station, TX

출판경험

Reactive oxygen metabolites inhibit spontaneous lymphatic contractions. Am. J. Physiol., 260: H1935- H1943, 1991. Inhibition of the active lymph pump in rat mesenteric lymphatics by hydrogen peroxide. Lymphology, 26: 135-142, 1993. Distribution, propagation, and coordination of contractile activity in rat mesenteric lymphatics. Am. J. Physiol., 264: H1283-H1291, 1993. Body position does not affect the hemodynamic response to venous air embolism in dogs. Anesth. Analgesia 79: 734-739, 1994. Myocardial edema and compromised left ventricular function attributable to dirofilariasis and cardiopulmonary bypass in dogs. Am. J. Vet. Res. 56: 221-226, 1995. Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Am. J. Physiol. 268: H178-H183, 1995. Myocardial edema left ventricular function and pulmonary hypertension. J. Applied Physiol. 78: 132-137, 1995. Normothermic continuous antegrade blood cardioplegia does not prevent myocardial edema and cardiac dysfunction. Circ. 92: 1940-1946, 1995. Myocardial fluid balance in acute hypertension. Microcirc. 3: 371-378, 1996. Cardiac surgical conditions induced by -blockade effect on myocardial fluid balance. Annals Thoracic Surg. 62: 143-150, 1996. Regulation of microvascular filtration in the myocardium by interstitial fluid pressure. Am. J. Physiol. 271: R1465-1469, 1996. Augmenting cardiac contractility hastens myocardial edema resolution following cardiopulmonary bypass and cardioplegic arrest. Anesth. Analgesia 85: 987- 992, 1997. Effect of body repositioning after venous air embolism: an echocardiographic study. Anesth. 86: 710- 717, 1997. Cooling gradients and formation of gaseous microemboli with cardiopulmonary bypass: an echocardiography study. Annals Thoracic. Surg. 64: 100-104, 1997. An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc. Natl. Acad. Sci. U S A 95(20): 11584-9, 1998. Beta-blockade as an alternative to cardioplegic arrest. Annals Thoracic. Surg. 65: 961-966, 1998. Increasing colloid osmotic pressure of normothermic blood cardioplegia decreases myocardial edema and increases cardiac function. Cardiovascular Surg. 6: 274-281, 1998. Contamination of lymph from the major prenodal cardiac lymphatic in dogs. Am. J. Physiol. 276(5 Pt 2): H1795-800, 1999. PMID:10330265 Variation in tau, the time constant for isovolumic relaxation, along the left ventricular base-to-apex axis. Basic Res. Cardiol. 94(1): 41-8, 1999. Nitrotyrosine formation with endotoxin- induced kidney injury detected by immunohistochemistry. Am. J. Physiol. 277 (1 Pt 2): F33-40, 1999. Effects of myocardial edema on the development of myocardial interstitial fibrosis. Microcirculation 7(4): 269-80, 2000. Myocardial protection with high-dose beta-blockade in acute myocardial ischemia. Eur. J. Cardiothorac. Surg. 17(1): 63-70, 2000. Esmolol and cardiopulmonary bypass during reperfusion reduce myocardial infarct size in dogs. Ann. Thorac. Surg. 72(6): 1964-9, 2001. CCAAT-binding factor regulates expression of the beta1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line. Proc Natl Acad Sci USA. 100(20): 11523-8, 2003. PMID: 14504408 Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylation. Crit. Care Med. 34(10): 2630-7, 2006. PMID: 16915113 Edema-induced intestinal dysfunction is mediated by Stat3 activation. Shock 28(2): 239-44, 2007. PMID: 17515852 Hypertonic saline modulation of intestinal tissue stress and fluid balance. Shock 29(5): 598-602, 2008. PMID: 1841433 Excess adenosine penile erectile tissues contribute to priapism via A2b adenosine receptor signaling. J. Clin. Invest. 118(4): 1491-1501, 2008. PMID: 18340377, PMCID: PMC2267015 Myocardial fluid balance in dogs with naturally acquired heartworm infection. Am. J. Vet. Res. 69(3): 356-361, 2008. PMID: 18312134 Hypertonic saline alters hydraulic conductivity and upregulates mucosal/submucosal aquaporin 4 in resuscitation induced intestinal edema. Crit. Care Med. 37(11): 2846-2952, 2009. PMID 19770732 Myocardial Function After Gut Ischemia/Reperfusion: Does NFkappaB Play a Role? J. Surg. Res. 152(2): 264-270, 2009. PMID: 18541267 A murine model for the study of edema induced intestinal contractile dysfunction. Neurogastroenterol Motil. 22(10): 1132-E290, 2010. PMID: 20591104, PMCID: PMC2939955 A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid. Surgery 148(2): 263-270, 2010. PMID: 20466401, PMCID: PMC2905488 Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction. J. Surg. Res. 163(1): 102-9, 2010. PMID: 20605598, PMCID: PMC3063554 Hydrostatic intestinal edema induced signaling pathways: potential role of mechanical forces. Surgery 147 (6): 772-9, 2010. PMID: 20097396, PMCID: PMC2875413 A novel physiological model for the study of abdominal compartment syndrome. J. Trauma 68(3): 682-689, 2010. PMID: 20220423, PMCID: PMC2875413 NF-kappaB Activation by Edema Inhibits Intestinal Contractile Activity. Crit. Care Med. 38(3): 861-870, 2010. PMID: 20168148 SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. Amer. J. Physiol. 302(2): G207-2017, 2011 PMID: 22038824, PMCID: PMC3341113 Sodium hydrogen exchanger as a mediator of hydrostatic edema induced intestinal contractile dysfunction. Surgery 149(1): 114-125, 2011. PMID: 20553904, PMCID: PMC2941706 Peritoneal fluid: a potential mechanism of systemic neutrophil priming in experimental intra-abdominal sepsis. Am. J. Surg. 203(2): 211-216, 2012. PMID: 21679918, PMCID: PMC3177024 A mathematical model of intestinal edema formation. Mathematical Med. Biol. 31(1): 1-15, 2014. PMID: 23036806 Time course of myocardial interstitial edema resolution and associated left ventricular dysfunction. Microcirc. 19(8): 714-722, 2012. (Award Article: Microcirculatory Society Award for Excellence in Lymphatic Research) PMID: 22708850, PMCID: PMC3502725 Ca2+/calmodulin-dependent Protein Kinase II Signaling in Enteric Nervous System. PloS One 7(8): e44426, 2012. PMID: 22952977, PMCID: PMC3432132 Decreased myosin phosphatase target subunit 1 (MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle. Neurogastroenterol. Motility 24(3): 257-266, 2012. PMID: 22235829, PMCID: PMC3321580 Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model. European J. Trauma Surg. 38(1): 65-73, 2012. Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility. J. Biol. Chem. 288(2): 1200-13, 2013. PMID: 23161543, PMCID: PMC3543003 Effects of traumatic brain injury on intestinal motility. Neurogastroenterol. Motility 25(7): 593-e463, 2013. (Featured in Nature Reviews Gastroenterology and Hepatology April 2013) PMID: 23551971 Intravenous multipotent adult progenitor cell therapy improves spatial learning after traumatic brain injury. Stem Cell Translation Med. 2(12): 953-60, 2013. PMID: 24191266, PMC3841090 Reduction in intestinal contraction rate is a key component in intestinal intussusceptions. Am. J. Physiol., Gastrointestinal Liver Physiol. 306(5): G445-53, 2014. PMID: 24407593, PMCID: PMC3949022 Suppression of contrac

자격증 및 수상경력

Life Technologies Training Center Workshop Award National Research Service Award Postdoctoral Fellowship National Heart, Lung and Blood Institute Frontiers in Digestive Diseases Symposium 2011. Third Place Poster Presentation Award. Certificate of Appreciation for Outstanding Performance and Lasting Contribution to Problem Based Learning Certificate of Appreciation for Outstanding Support of Summer Research Program Dean’s Teaching Excellence Award

경력

Instructor, University of Texas Medical School – Houston Dept. Integrative Biology and Pharmacology Houston, TX Instructor, University of Texas Medical School – Houston Dept. Pediatric Surgery Houston, TX Assistant Professor, University of Texas Medical School – Houston Dept. Pediatric Surgery Houston, TX Faculty, Michael E. DeBakey Institute, Texas A&M University, College Station, TX Associate Faculty, University of TX Graduate School of Biomedical Sciences Houston, TX Adjunct Faculty, University of Texas Medical School – Houston Dept. Integrative Biology and Pharmacology Houston, TX Associate Professor, University of Texas Medical School – Houston Dept. Pediatric Surgery Houston, TX Associate Professor, University of Debrecen Department of Medicinal Chemistry Debrecen, Hungary

회원활동

American Gastroenterological Association American Society of Cell Biologists American Neurogastroenterology and Motility Society Mission Connect, Houston, TX American Society for Biochemistry and Molecular Biology American Society of Pharmacology and Experimental Therapeutics